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  • Trimethoprim (INN) (pronounced /traɪˈmɛθəprɪm/) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections. It belongs to the class of chemotherapeutic agents known as dihydrofolate reductase inhibitors. — “Trimethoprim - Wikipedia, the free encyclopedia”,
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  • The use of dihydrofolate reductase inhibitors, including trimethoprim, during pregnancy may increase the risk of congenital anomalies including The American Academy of Pediatrics considers trimethoprim in combination with sulfisoxazole to be "usually compatible with breast-feeding. — “Trimethoprim: Drug Information Provided by Lexi-Comp: Merck”,
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